The result of present study underlines the mediatory role of 13(S)-HODE for the induction of apoptosis in breast cancer cells and provides evidence on the possible relevance of PPAR-δ in the regulation of cell growth mediated by 13(S)-HODE; however, further studies are needed to clarify the specific role of PPAR family. The gene discussed is PPARD; the disease is breast carcinoma.