This results in a reduction of lymphocyte migration through BBB and also reduces uptake and presentation of antigen by macrophage and dendritic cells.36, 37 Activated microglia in cortical neurons secrete some inflammatory cytokines, such as TNF-α, IL-1β, glutamate, superoxide, and nitric oxide, which are all neurotoxin factors and cause neural injury in MS patient. The gene discussed is TNF; the disease is myeloid sarcoma.