IRF1 and myeloid sarcoma: There is much evidence that confirm the decreasing of IFNβ production in MS patients.14 As a result, the level of IFNB-stimulated genes, especially IFNβ (IFNβ stimulate their own secretion) production, are eliminated.15 As mentioned before, after IFNβ binds to its receptor there is a rapid formation of ISGF3 complex, and elevation of several gene transcriptions, such as IRF1, IFNβ bind to their receptors and trigger JAK-STAT signaling pathway which promote antiviral, antitumor, and anti-inflammation effects (Details are given in the text).