In recent studies evaluating various biomarkers, including atrial and brain natriuretic peptides, CRP, and homocysteine, in outcome of stable cardiovascular diseases showed that CRP was associated with an increased risk of congestive heart failure.24 Thus there is increasing evidence that hsCRP is a risk as well as prognostic factor for ischemic stroke and coronary events.10, 20, 25, 26. This evidence concerns the gene NPPB and cardiovascular disorder.