Zacho et al., in his population based study, found a high frequency of ischemic heart disease (32%) and ischemic stroke (25%) among patients with high levels of CRP in Denmark.21 Ridker et al. from the US, showed high CRP to be a predictor of risk for future myocardial infarction and stroke in healthy men.22 Among the Japanese population Arima et al. showed a significant association between high hsCRP and future risk of coronary artery disease.23 Moreover, CRP has also been associated with poorer outcomes in cardio and cerebrovascular diseases. This evidence concerns the gene CRP and myocardial infarction.