Adipose tissue secretes cytokines that influence the immune system function, including leptin, and interleukin-6, both of which have been shown to reduce regulatory T cell activity.24–27 The elevation of leptin levels were inversely correlated with frequency of regulatory T cells in MS patients.4 There are several studies which suggest the pathogenesis of the effects of leptin hormone in MS patients.5, 6, 22, 28. This evidence concerns the gene LEP and myeloid sarcoma.