The association between migraine and obesity has also been reported.3, 4 Studies also suggest a relationship between obesity and migraine frequency and severity as well as migraine features such as phonophobia and photophobia.1 Subcutaneous fat, especially in the gluteofemoral region in women, seems to increase leptin and adiponectin secretion. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.