Statistical comparison between single agent therapy versus combination revealed a major synergy between arsenic and IFN in both BC-3 and BCBL-1 mice (p<0.001 for both) whereas AZT and IFN displayed a more synergistic effect in BC-3 mice (p<0.001) as compared to BCBL-1 mice (p<0.05) (Figure 1D). Here, IFNA1 is linked to breast cancer.