Thus, the suppression of proinflammatory cytokine production by AF-08 early in the infection was associated with weakening inflammation in the lungs of infected mice and reducing the infiltrated cell population quantitatively and/or qualitatively, resulting in suppression of the overreaction of Th1 immune response correlated with the elevation of IFN-γ level in the infected lungs. This evidence concerns the gene IFNG and infection.