Therefore, in the present study, we performed a randomized, double-blind, placebo-controlled trial to evaluate the effects of Berberis vulgaris fruit extract on serum lipoproteins, apoB, apoA-I, homocysteine, and glycemic control and total antioxidant capacity (TAC) in type 2 diabetic patients. The gene discussed is APOB; the disease is type 2 diabetes mellitus.