In addition, Pg extracts and punic acid, an omega-5 long chain poly unsaturated fatty acid derived from Pg, have been shown to induce apoptosis in both an estrogen in sensitive breast cancer cell line (MDA-MB-231) and an estrogen sensitive cell line developed from MDA-MB-231 cells (MDA-ERalpha7) through lipid peroxidation and the PKC (Protein kinase C) signaling pathway (69). This evidence concerns the gene JUP and breast carcinoma.