As can be seen from Table 3, the treatment of the SHRs with hypotensive drugs (PR, MT, ID, and AM) did not affect major glucose metabolism indices in serum, such as glucose, insulin, and homeostasis model of assessment—insulin resistance (HOMA IR), except in the case of ID, where glucose levels increased (by 11.5 %). The gene discussed is INS; the disease is Insulin resistance.