In summary, at clinical doses, lithium, valproate, and sertaline have each increased striatal BDNF levels (and sertraline increased striatal neurogenesis) in two different HD transgenic mouse models while single studies indicate lithium stimulated striatal neurogenesis in the quinolinate rat and that very high dose fluoxetine stimulated hippocampal neurogenesis and preserved hippocampal volume in the R6/1 mouse. The gene discussed is BDNF; the disease is Huntington disease.