In summary, there is preliminary evidence of mitochondrial protective effects for antipsychotics (haloperidol, trifluoperazine), antidepressants (imipramine, nortriptyline, desipramine, maprotiline, trazodone, sertraline, venlafaxine), and the hypnotic melatonin in a number of different HD models that include several huntingtin striatal cultures, YAC128 transgenic mice, and the 3-nitropropionate rat. The gene discussed is HTT; the disease is Huntington disease.