Although high dose sertraline failed to reduce huntingtin aggregation in either the R6/2 or N171-82Q transgenic mouse, unreplicated HD cell culture (high dose) and animal model (extreme dose) studies indicate that haloperidol reduced aggregation, while high dose lithium reduced aggregation in two HD cell culture models and stimulated autophagy in four, but replication is still needed at human therapeutic concentrations. The gene discussed is HTT; the disease is Huntington disease.