REST and Huntington disease: A review of the published medical literature disclosed no articles in HD models regarding psychotropic effects on HTT CAG repeats, the modifying genes listed above, or REST. Although there is no way to know if any of the findings in non-HD models can potentially translate to HD, a few results were found for modifying genes and for REST (An analysis of GEO Profiles data for modifying genes other than HTT is beyond the scope of this article).