Peng and colleagues administered clinically relevant doses of the antidepressant sertraline (5–10 mg/kg/day, about 3.5 times the human therapeutic dose) for 10 weeks to R6/2 HD transgenic mice but did not find reductions in intranuclear aggregated huntingtin protein in striatal, hippocampal, or cortical neurons [47]. The gene discussed is HTT; the disease is Huntington disease.