In neuropathological non-HD models, other drugs neuroprotectively downregulating AP-1 DNA binding activity include valproate in the kainic acid seizure model [118], carbamazepine in the carbachol stimulation model [109], and diazepam [118] and dextromethorphan [119–121] in the kainic acid seizure model while none pro-apoptically upregulated AP-1 DNA binding. The gene discussed is JUND; the disease is Huntington disease.