Loxapine (1–10 μM) and cyproheptadine (1–10 μM) each blocked caspase-3 activation and rescued mouse striatal cells expressing mutant Htt (exon 1 with 111 repeats) from cell death in the Hdh (Q111/Q111) mouse striatal cell model, thought to be mediated by transient phosphorylated activation of ERK that was subsequently associated with reduced neurodegeneration and improved motor performance in R6/2 HD transgenic mice treated with the related drug pizotifen [155]. The gene discussed is CASP3; the disease is Huntington disease.