The combination of NT-proBNP and PFT achieved a high sensitivity and NPV of 94.1% and 92.3%, respectively, which was at least comparable to the current ESC/ERS screening guidelines in this cohort, and broadly comparable to the recently presented DETECT study in which patients selected for risk of PAH based on DLCO <60% all had RHC [18]. This evidence concerns the gene NPPB and pulmonary arterial hypertension.