A number of studies have reported the potential utility of NT-proBNP in SSc-PAH, including the study by Allanore et al. wherein a high NT-proBNP level (>97th percentile of normal) identified SSc patients who went on to develop pre-capillary pulmonary hypertension (pre-CPH) over a median follow-up period of 29 months [15-18]. Here, NPPB is linked to systemic sclerosis.