TP53BP2 and breast cancer: According to a previous study, 4.1% and 1.5% of p53 binds with ASPP1 and ASSP2, respectively, in normal cultural MCF-7 BC cell line, p53-ASPP2 complexes increase to 3.4 times after the cells are UV-irradiated, and p53-ASPP1 complexes remain unchanged [6].