In the present study, we showed that pdBSI in young rats increased shortly after Et-1 (at 15 and 60 min) compared with recordings before Et-1, while in aged rats pdBSI after ischemia was greater than pdBSI before ischemia or pdBSI in young rats during the whole experimental period (up to 14 days post-Et-1). This evidence concerns the gene EDN1 and ischemia.