Median disease duration was 9 years (4 to 15 years), median CRP was 1.7 mg/l (0.5 to 5.5 mg/l) and median DAS28 ESR was 3.1 (2.5 to 4.1), and most patients in this study had low disease activities of RA. The gene discussed is CRP; the disease is rheumatoid arthritis.