ESR1 and breast cancer: The better prognosis that is seen for Bcl-2-positive breast cancer had thus been attributed to its higher prevalence of ER expression; however, Dawson et al. [9] demonstrated Bcl-2 expression to be associated with a good prognosis independent of ER expression, by comparing the associations between Bcl-2 expression and the prognosis of an ER positive group with that of an ER negative group separately.