Nakajima et al. [24] also reported the most prevalent histologic type in ER/PR + HER2- and ER/PR + HER2+ to be scirrhous carcinoma, while the frequency of solid-tubular carcinoma was as high as that of scirrhous carcinoma at 34% in basal-like type [24]. This evidence concerns the gene ESR1 and carcinoma.