Even though human genetic polymorphisms in TLR 2 or 6 genes have not been indicated in RSV pathogenesis [75], a recent investigation, studying the associations and interactions of genetic polymorphisms of innate immune genes with early viral infections and susceptibility to asthma and asthma-related phenotypes, found evidence that TLR1 (rs4543123) polymorphism interacts with RSV infection to modify the risk for atopic asthma [76]. This evidence concerns the gene TLR1 and asthma.