Since then many studies have confirmed the increase of total CSF tau protein concentration in AD patients compared to controls (Kandimalla et al., 2011a; Kandimalla et al., 2011b; Tapiola et al., 2009; Haense et al., 2008; Hampel et al., 2003; Andreasen et al., 2003). The gene discussed is MAPT; the disease is Alzheimer disease.