Despite markedly different vascular pathologies promoted by chronic AngII infusion, the present study provides evidence that continuous infusion of a dihydropyridine calcium channel blocker, amlodipine, has pronounced effects on inhibition of these diverse pathologies that developed in mice rendered hypercholesterolemia by deletion of LDL receptor and feeding a diet that has a high saturated fat content (42% by calories), compared to normal laboratory diet (18% fat by calories). The gene discussed is LDLR; the disease is Hypercholesterolemia.