Furthermore, in the case of some patients, IgE reactivity to OM could not be inhibited by pre-incubation with dOM (Figure 2c-l), what indicates that these patients might be sensitized not only to the peptide epitopes, but also to carbohydrate-containing structures, although cross-reactivity between carbohydrate-containing and amino acid structures could not be excluded. The gene discussed is IGHE; the disease is ocular melanoma.