Multivariate analysis revealed tumor stage (hazard ratio (HR)=2.76, 95% confidence interval (CI): 1.14-6.66 P = 0.024), strong HA expression (HR=6.04, 95%CI: 1.42-25.69 P=0.015), and weak HYAL1 expression (HR=3.16, 95%CI: 1.19-8.40 P=0.021) (Table 3). The gene discussed is HYAL1; the disease is neoplasm.