Although UICC stage and residual tumor were also identified as significant prognostic factors in univariate analysis, the P-values for strong HA expression (P=0.015) and weak HYAL1 expression (P=0.021) were lower than those of UICC stage (P=0.024) and residual tumor (P=0.277) in multivariate analysis. Here, HYAL1 is linked to neoplasm.