According to a prevailing proposal, the mutation patterns observed by cancer cell large scale sequencing, documenting TP53, ataxia telangiectasia mutated (ATM) and cyclin-dependent kinase inhibitor 2A (CDKN2A; which encodes p16INK4A and p14ARF) mutations, support the oncogene-induced DNA replication stress model, which attributes genomic instability and TP53 and ATM mutations to oncogene-induced DNA damage [1]. This evidence concerns the gene TP53 and cancer.