The LRRK2 G2019S mutation in the kinase domain appears to increase its enzymatic activity [12] and since LRRK2-related PD and sporadic PD display a similar phenotype [13], pharmaceutical companies are pursuing LRRK2 kinase inhibitors to reduce this gain-of-function as a promising therapeutic option for people with PD. The gene discussed is LRRK2; the disease is Parkinson disease.