Different integrin receptors have been reported to bind the EDA: the α4β7 integrin partially mediates adhesion to FN EDA+ in murine and human lung fibroblasts [24], α4β1 was reported as EDA receptor in human melanoma cells [47], and α9β1 integrin was also proposed as the FN EDA+ specific receptor in multiple models [42,47–50]. This evidence concerns the gene FN1 and melanoma.