To investigate the contribution of the small GTPases Rac-1 and RhoA to the processes leading to progressive chronic renal failure, the 5/6Nx mice and their sham operated counterparts were treated with a set of inhibitors: the HMG-CoA reductase inhibitor Rosuvastatin, the ACE inhibitor Ramipril, the Rac-1 inhibitor EHT1864 and the ROCK (a downstream protein kinase of Rho) inhibitor SAR407899. This evidence concerns the gene RHO and chronic kidney disease.