TBX1 and hereditary disease: 22q11.2 Deletion Syndrome (22q11DS, OMIM #188400), also commonly known as DiGeorge Syndrome or Velo-Cardio-Facial Syndrome, is a genetic disorder that results from an approximately 1.5-3Mb congenital multigene deletion on the long arm of chromosome 22, which includes the gene for T-Box Transcription factor 1 (TBX1) [1,2].