The level of circulating Lin28B had a significant association with high BCLC stage (stage B to C diseases versus A1 to A4 diseases) (P=0.022) (Figure S6A) and had a borderline significance in associated with high AJCC stage (stage IIIC to IVA diseases versus I to IIIB diseases) (P=0.066) (Figure S6B). This evidence concerns the gene LIN28B and glycogen storage disease VI.