MEIS1 and neoplasm: Univariate analysis, which considers individual variables contributing to MEIS1 promoter methylation (BRAF mutation status, MSI status, and tumor location), showed that BRAFp.V600E had the highest association with MEIS1 promoter methylation (OR = 13.0, CI = 5.2 - 33.0, P = 0.0001; Table 2).