Furthermore, in a large-scale multicentre trial Hermansen et al [22] demonstrated that the combination of the basal-bolus regimen (insulin detemir and insulin aspart) provided a significant reduction in HbA1c by 0.22% when compared with traditional insulins (NPH and human regular insulin) in patients with type 1 diabetes after 18 weeks of treatment. Here, INS is linked to type 1 diabetes mellitus.