AKT3 and hepatocellular carcinoma: In summary, our data demonstrate that AKT3 expression is inversely correlated to miR-122 levels in HCC cell lines, and that over-expression of miR-122 in a subset of HCC cell lines decreases AKT3 mRNA and protein levels by directly binding to the 3’UTR of AKT3, which subsequently leads to inhibition of cell proliferation and migration.