While these latter studies utilized the prostate cancer cell lines, PC3 and PC3-AR, and immortalized normal prostate RWPE-1 cells as experimental models, it is well known that PC3 cells are AR-, p16INK4a- and p53-null [39], and RWPE-1 cells are p53- and Rb-null [41]. The gene discussed is CDKN2A; the disease is prostate cancer.