Dose-dependent suppression of BRCA1, CHK1, and RAD51 transcript and protein expression was also detected in CTS, U937, and OCI-AML3 AML cell lines (Figures 1G&I–K, BRCA1 was barely detectable in the U937 cells, and thus drug effects are difficult to interpret). The gene discussed is CHEK1; the disease is acute myeloid leukemia.