To elucidate the relationship of SLD5 to cancer cell growth in tumor progression in vivo, we investigated oncogenesis in the Wnt1/C2mE transgenic mouse, a genetic model of spontaneous gastric carcinogenesis [15], on an SLD5+/− background (SLD5+/−/Wnt1/C2mE). This evidence concerns the gene GINS4 and neoplasm.