We tested the effects of exogenous administration of HSA-Flag-TWEAK, a recombinant variant of the naturally occurring soluble form of the multi-functional cytokine TWEAK which, together with its receptor Fn14, is robustly up-regulated after MI and can influence cardiac repair [32], ischemic tolerance [12], inflammatory processes, and apoptosis [9]. Here, TNFSF12 is linked to myocardial infarction.