The ALDHlow CD34+CD38– cell compartment segregated, in some AML cases, in a population which could be inhibited by DEAB and a population which could not (Figure S1, AML-1048), suggesting the existence of LSC populations with various levels of ALDH activity within one CD34+CD38– ALDHlow compartment. This evidence concerns the gene CD38 and acute myeloid leukemia.