To confirm that the ALDHbright CD34+CD38– cells are normal HSC and the ALDHlow CD34+CD38– cells are LSC we analysed the presence of molecular aberrancies in the ALDH compartments from CD34-positive AML cases with two molecular aberrancies, FLT3-ITD and mutated NPM1 (AML-575 and AML-808). The gene discussed is LDHA; the disease is acute myeloid leukemia.