We also evaluated the gene expression data for ICOS and ICOS-ligand (ICOSLG) expression in the different lymphoma subsets, assuming cases with log2 expression values ≥7.0 to show an expression of these transcripts: ICOS was expressed in this independent set of cases only in rare cases (3 cases typical NLPHL, 1 case THRLBCL-like NLPHL, 2 cases THRLBCL), whereas ICOSLG was expressed in all cases as well as in the GC B cells. Here, ICOSLG is linked to lymphoma.