In addition, clinical as well as experimental studies have shown that the AMPK activators metformin [18], [19] or 5-aminoimidazole-4-carboxamide ribonucléotide (AICAR) [20], [21] can prevent diabetes in at risk patients or in the Zucker Diabetic Fatty rat (a model of obesity becoming spontaneously diabetic), respectively. Here, PRKAA2 is linked to diabetes mellitus.