MYC and colorectal carcinoma: Guo et al demonstrated in CRC HT29 cell line, NGX6 gene product inhibited transferring of the β-catenin from the nucleus and cytoplasm to the cell membrane, thereby inhibiting the transcriptional activity of TCF and down-regulating the expression of Wnt target genes c-Myc, cyclinD1 and COX-2, leading to decreased cancer cell invasion and metastasis [16].