Being the key transcriptional activation factor of Wnt/β-catenin signal pathway, upon upstream activation, β-catenin often translocates to the nucleus from cytoplasm, in coordination with other transcription factors such as TCF/LEF, to activate its target genes c-Myc, cyclinD1, MMP-7, and CD44, which in turn play pivotal role in tumor initiation and development [27]–[30]. The gene discussed is CD44; the disease is neoplasm.