In another study, Nagai et al suggested that treatment with sorafenib and U0125 (a MEK inhibitor) of Huh7 and HepG2 markedly inhibited the HGF-induced EMT by inhibiting EMT-like morphologic changes, snail expression and E- to N-cadherin switching and thus completely canceled the HGF-mediated cellular migration in HCC cells [38]. This evidence concerns the gene HGF and hepatocellular carcinoma.