PRKN and Parkinson disease: Whereas only three candidate proteins are known Parkin-binding proteins according to HNet (DNAJA1, HSPA1A, HSPA8) [23], 164 interact with Parkin through one intermediate protein, and 40 interact with one or two other proteins known to be involved in monogenic parkinsonism, which suggests that they might function together in a PD-specific pathway.