PRKN and Parkinson disease: As expected, the most significant pathways according to ConsensusPathDB were “Parkinson's disease” (P = 1.6×10−14), “Alpha-synuclein signaling” (P = 1.1×10−08), and “Role of parkin in ubiquitin-proteasomal pathway” (P = 1.5×10−07) (Table S4).