CRP and anemia: While we cannot exclude the possibility for increased anemia since introduction of the CDS/CRP-guided antibiotic use protocol, we do not expect a significant effect on anemia for the following reasons: 1) CRP values were almost always obtained at time of other routine laboratory tests (blood culture, CBC, bilirubin etc.)and 2) we only measured 2 CRP values within 48 hours followed by one additional value at 7 days of antibiotics in case initial CRP values suggested infection and a decision to treat was made.