In contrast, significantly higher numbers of CCR1+, CCR5+, CXCR3+, CXCR4+ and CXCR6+ T cells were found in the livers of WSX-1−/− mice on day 14 of infection than in infected WT mice (Fig. 2G), due primarily to the significant increase in total CD4+ T cells accumulating in the livers of WSX-1−/− mice during infection (Fig. 1A–C). The gene discussed is CCR1; the disease is infection.