The median CYP11A1 mRNA level in the CRPC metastases was 0.41 times compared to the level in the primary tumor tissue (P = 0.011, figure 2), while the CYP17A1 and HSD3B2 mRNA levels in CRPC bone metastases were not significantly different from levels in the primary tumor tissue. This evidence concerns the gene CYP11A1 and neoplasm.