The median CYP11A1 mRNA level in the CRPC metastases was 0.41 times compared to the level in the primary tumor tissue (P = 0.011, figure 2), while the CYP17A1 and HSD3B2 mRNA levels in CRPC bone metastases were not significantly different from levels in the primary tumor tissue. Here, CYP17A1 is linked to neoplasm.