FOXP3, an X-linked suppressor of autoimmune disease and cancers, increases both H4K16 acetylation and H3K4 trimethylation at the FOXP3-associated chromatins of multiple FOXP3-activated genes by recruiting MOF and displacing histone H3K4 demethylase PLU-1 [29]. This evidence concerns the gene FOXP3 and cancer.