When the changes in utilization of each identified pA site from lytic to latent infection were calculated, however, the usage of mapped pA sites for virus lytic gene expression became remarkable, with more than 500-fold increase from latent to lytic infection for ORF62, ORF24/23, ORF44, PAN, and K12 (Figure 2C, Table S6). Here, ADA2 is linked to disease arising from reactivation of latent virus.