Individual staining for MAP4K4 and LANA of adjacent serial sections of a KS biopsy also indicated the increased expression of MAP4K4 in LANA-expressing KS spindle cells, although a lower level of MAP4K4 expression could also be seen in other cells in the tumour (figure 8B–C), and a basal expression of MAP4K4 was observed in the surrounding connective tissue (figure 8C), in line with another report showing low levels of MAP4K4 cytoplasmic staining in non-neoplastic lung tissues, compared to strong expression in lung adenocarcinomas [82]. This evidence concerns the gene MAP4K4 and neoplasm.