It should be noted, however, that the NK cell-specific Il-10 deletion efficacy was only 63% (Figure S6 and [50]), but in combination with the observation that NK cell depletion did not lead to an overall reduction in IL-10 mRNA on day 2 post infection it is rather unlikely that NK cell produced IL-10 plays a decisive role in promoting LCMV chronicity. The gene discussed is IL10; the disease is infection.