Analysis on day 5 post infection revealed that CD8+ T cell depleted mice expressed similar overall levels of IL-10 mRNA as undepleted controls (Figure 2E), while CD4+ T cell depleted, clodronate liposome treated mice and DC specific IL-10 knockout mice (Il-10fl/flxCD11c-Cre+ mice) exhibited reduced levels (Figure 2F–H). The gene discussed is CD8A; the disease is infection.