DUSP1 and infection: Finally, we skin-scarified groups of DUSP1 WT and KO mice with MVA (2×107 PFU/mouse tail) and after 8 days post-infection we observed that lesions in the tails of KO mice were more severe than in their WT counterparts (Fig. S3); these lesions were not observed in media or PBS-scarified KO mice indicating that the inflammatory lesions were solely due to the virus inoculum.