DUSP1 KO mice experienced a significant (higher dose, day 3: p<0.005; low dose, day 4: p<0.05) more accelerated weight loss than their wild-type littermates during the course of the infection, with a reduction of 25% (high dose) or 21% (low dose) at day 5 post-infection (Fig. 9A). Here, DUSP1 is linked to infection.