SMG5 and cancer: However, in ESCC the chimera GOLM1-MAK10 appears to be highly enriched while the two most prominent prostate cancer chimeric RNA, SLC45A3-ELK4 and TMEM79-SMG5 [6], and the fusion transcript from the prostate cancer fusion gene TMPRSS2-ERG [22], are undetectable in ESCC (Figure 2), indicating that the different cancer types posses different prominent molecular signatures with respect to chimeric RNA species.