In parallel studies for downregulated genes, we were able to identify seven genes with mutations in colon cancer (DPP10, PCSK2, ADAM33, RELN, CAPN13, ADAMTS1 and ADAMTS15), and five genes with mutations in breast carcinomas (MASP3, ABHD12B, TLL1, CPA3 and DPP6). Here, PCSK2 is linked to malignant colon neoplasm.